Spring 2025
By Samantha Sullivan
ChadTough Defeat DIPG Foundation is committed to funding the most promising childhood brain cancer research worldwide. To further support their mission, the foundation made a gift of $600,000 through their Game Changer Grant program to support research under the direction of Mariella Filbin, MD, PhD, research co-director in the Pediatric Neuro-Oncology Program at Dana-Farber.
All human cells contain identical genetic information, yet they differentiate into various types with unique structures and functions due to epigenetic regulation. This involves modifications to DNA and its supporting proteins, influencing gene expression and determining cell fate during development. Diffuse midline glioma (DMG) in the pons is also known as a diffuse intrinsic pontine glioma (DIPG). In DMG, a mutation in histone 3 disrupts this regulation, causing tumor cells to proliferate uncontrollably, instead of completing their original cell fate trajectory.
“Together, we are changing the story for kids and families, creating a legacy of hope, progress, and love.”
Ann Friedholm, ChadTough Defeat DIPG Foundation
Traditional methods have limited our understanding by separating the study of epigenetic regulation from the study of gene expression. However, new technologies now enable simultaneous analysis of both in the same cell. By integrating these technologies with genetic tools to remove the histone 3 mutation, researchers can gain insights into how this mutation triggers oncogenic gene expression and alters cell fate.
Filbin’s research aims to deepen understanding of DMG progression and develop new treatments to redirect tumor cells to their intended developmental paths, thereby halting their division.
“Through this gift, we hope to accelerate progress toward a cure for DIPG by supporting innovative and impactful research,” says Ann Friedholm, CEO at ChadTough Defeat DIPG Foundation. “Together, we are changing the story for kids and families, creating a legacy of hope, progress, and love.” ChadTough Defeat DIPG Foundation was founded in 2015 after two families lost their sons, Chad Carr and Michael Mosier, to this devastating disease. The families channeled their heartache into action by creating the foundation to find a cure for pediatric brain cancer and aim for a world where children diagnosed with DIPG/DMG can live long, healthy lives.